| 2021-09-25 15:00:4325/09/2021 | Foggia Primavera-Palermo Primavera | 1 - 4 | Primavera 3 - Girone C 2021/22 | N/D |
| 2021-10-02 15:00:0502/10/2021 | Palermo Primavera-Potenza Primavera | 5 - 0 | Primavera 3 - Girone C 2021/22 | N/D |
| 2021-10-09 15:00:5509/10/2021 | Catania Primavera-Palermo Primavera | 0 - 0 | Primavera 3 - Girone C 2021/22 | N/D |
| 2021-10-16 15:00:3016/10/2021 | Palermo Primavera-Bari Primavera | 3 - 1 | Primavera 3 - Girone C 2021/22 | N/D |
| 2021-10-23 15:00:1123/10/2021 | Virtus Francavilla Primavera-Palermo Primavera | 0 - 2 | Primavera 3 - Girone C 2021/22 | N/D |
| 2021-11-07 14:30:1107/11/2021 | Avellino Primavera-Palermo Primavera | 1 - 2 | Primavera 3 - Girone C 2021/22 | N/D |
| 2021-11-13 15:00:5913/11/2021 | Palermo Primavera-Paganese Primavera | 5 - 0 | Primavera 3 - Girone C 2021/22 | N/D |
| 2021-11-20 15:00:3620/11/2021 | Catanzaro Primavera-Palermo Primavera | 0 - 0 | Primavera 3 - Girone C 2021/22 | N/D |
| 2021-11-27 15:00:1727/11/2021 | Palermo Primavera-Monopoli Primavera | 3 - 1 | Primavera 3 - Girone C 2021/22 | N/D |
| 2021-12-04 15:00:0304/12/2021 | Palermo Primavera-Foggia Primavera | 4 - 1 | Primavera 3 - Girone C 2021/22 | N/D |
| 2021-12-11 15:00:4911/12/2021 | Potenza Primavera-Palermo Primavera | 0 - 0 | Primavera 3 - Girone C 2021/22 | N/D |
| 2022-01-22 14:30:3922/01/2022 | Palermo Primavera-Catania Primavera | 2 - 2 | Primavera 3 - Girone C 2021/22 | N/D |
| 2022-01-29 15:00:2329/01/2022 | Bari Primavera-Palermo Primavera | 1 - 1 | Primavera 3 - Girone C 2021/22 | N/D |
| 2022-02-05 15:00:0205/02/2022 | Palermo Primavera-Virtus Francavilla Primavera | 0 - 0 | Primavera 3 - Girone C 2021/22 | N/D |
| 2022-02-19 15:00:0919/02/2022 | Palermo Primavera-Avellino Primavera | 3 - 2 | Primavera 3 - Girone C 2021/22 | N/D |
| 2022-02-27 15:00:5227/02/2022 | Paganese Primavera-Palermo Primavera | 2 - 1 | Primavera 3 - Girone C 2021/22 | N/D |
| 2022-03-05 15:00:2905/03/2022 | Palermo Primavera-Catanzaro Primavera | 1 - 1 | Primavera 3 - Girone C 2021/22 | N/D |
| 2022-03-12 15:00:1712/03/2022 | Monopoli Primavera-Palermo Primavera | 1 - 1 | Primavera 3 - Girone C 2021/22 | N/D |
| 2022-03-26 14:30:5126/03/2022 | Catanzaro Primavera-Palermo Primavera | 1 - 1 | Primavera 3 - Playoff 2021/22 | N/D |
| 2022-04-02 15:00:1802/04/2022 | Palermo Primavera-Catanzaro Primavera | 2 - 0 | Primavera 3 - Playoff 2021/22 | N/D |
| 2022-04-10 11:00:5310/04/2022 | Palermo Primavera-Padova Primavera | 1 - 3 | Primavera 3 - Playoff 2021/22 | N/D |
